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Chlorine Dioxide: Scientifically Proven Cure For Bad Breath A safe, buffered solution of activated chlorine dioxide is recognized as highly effective in killing bad breath germs, and neutralizing the volatile sulfur compounds
(VSC) they produce in the mouth, and exhaled as bad breath. Target Laboratories has developed a convenient, single-use, easy to use kit that contains a special cotton tongue swab, used for applying the activated chlorine dioxide to the tongue’s surface. The cotton swab is first wrapped around the index finger, and held in place by an adhesive backing. A small vial of diluted, buffered chlorine dioxide is poured onto the surface of the tongue swab, followed by a small vial of a naturally flavored activator. The user simply swabs the top surface of the tongue, concentrating on the back of the back of the surface, wiping away mucous, food particles and debris. The chlorine dioxide soaked cotton swab kills and sweeps away bad breath germs on contact, and instantly neutralizes and noxious volatile sulfur compounds
(VSC) that are exhaled as bad breath. Science Supporting Chlorine Dioxide Molecular chlorine dioxide (ClO2) is recognized as an effective and safe oxidant and antimicrobial agent. Because of its high oxidative tendency, chlorine dioxide is readily able to oxidize and neutralize certain chemical groups found in organic compounds, specifically volatile sulfur compounds (VSCs). Upon oxidation, mercaptans, sulfides and disulfides lose most if not all of their malodor properties. Chlorine dioxide is an unstable molecule when dissolved in water of near-neutral pH. In aqueous solutions having a pH of about 6 to about 8, chlorine dioxide deteriorates rapidly to the chlorite and chlorate ions. The instability of aqueous chlorine dioxide has limited its utility to those applications where the aqueous chlorine dioxide can be used at a specific concentration immediately upon its formation, during the time period when sufficient chlorine dioxide exists, in a continuously degrading solution, to effect its intended task. The oral hygiene patent is directed to processes and antimicrobial compositions in which an organic acid in the concentration range of about 0.01% to about 3% is combined with an aqueous metal chlorite at a concentration of about 0.0001% to about 0.4%. The technology deployed in treating oral malodor with a diluted, buffered solution of chlorine dioxide involves contacting an area of the tongue surface in need thereof with the aqueous mix so as to contact contamination thereon for a period of time; removing at least a portion of the contacted contamination and used aqueous mix from the area of the tongue surface; optionally, repeating the contacting and removing steps so as to effect a desired degree of cleaning. A two-part chlorine dioxide disinfecting system adapted to be mixed to yield an aqueous disinfecting composition, wherein the first part comprises a diluted, buffered chlorite and the second part comprises an acid and naturally flavored oxidizable colorant. Chlorine dioxide disinfectants are commonly two-part products having a "base" part containing a chlorite (such as sodium chlorite) and a second or "activator" part containing an acid activator. The disinfectant is formed upon mixing the first and second part, and when combined and mixed together, form a disinfecting composition having effective utility in treating oral malodor. Acidified chlorite compositions may be generated by combining chlorite (i.e., ClO.sub.2.sup. -), typically in the form of a metal salt such as sodium chlorite, with an acid activator. Such compositions are effective disinfectants due to the generation of antimicrobial oxidants, particularly chlorous acid (i.e., HClO.sub.2). Chlorous acid is formed very rapidly upon acidification of chlorite in an equilibrium process governed by the solution pH. Chlorous acid can subsequently undergo a series of chemical reactions to form chlorine dioxide. Chlorine dioxide is known to significantly inhibit the formation of sulfur containing anions in the oral cavity and prevent a reduction of the oxidation potential of the oral cavity comprising delivering into the oral cavity a therapeutically effective amount of an oral composition.
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The hard and soft tissues of the mouth are covered with microbial populations that contain bacteria with different metabolic capabilities. The Gram-negative bacteria, especially the anaerobes readily metabolize various amino acids contained in salivary (and to lesser extent other) peptides and proteins in the oral cavity to form end products, which favor the formation of oral malodor. This process of peptide, protein and amino acid degradation by the mouth bacteria is referred to as oral bacterial putrefaction. The mixture of malodorous compounds produced by the Gram-negative anaerobic bacteria during putrefactive degradation of proteins, peptides and amino acids include hydrogen sulfide, methyl mercaptan, and dimethyl sulfide (formed from the sulfur containing amino acids cysteine, cystine and methionine); indole and skatole (formed during the metabolism of tryptophan); cadaverine and putrescine (produced from lysine and ornithine); and butyrate and valerate (produced from the metabolism of other amino acids). The production of these malodorous compounds in the oral cavity results in a condition commonly referred to as oral malodor. Examples of suitable metal chlorites include calcium chlorite, barium chlorite, magnesium chlorite, lithium chlorite, sodium chlorite and potassium chlorite. Sodium chlorite and potassium chlorite are preferred. Sodium chlorite is particularly preferred. Mixtures of two or more sources of chlorite may also be used. A convenient means of dispensing the two-part treatment solution involves the use of liquid volumes that can be contained in the separate sealed vials. It incorporates the use of a cotton tongue swab with an adhesive backing, which is wrapped around the index finger and used to wipe the upper dorsal surface of the tongue.
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